| D1 | 30/04/1910 | Preston North End | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 23/04/1910 | Bolton Wanderers | 0-2 | Tottenham Hotspur | | | Unknown | Loss |
| D1 | 16/04/1910 | Bury | 1-2 | Bolton Wanderers | Jones G, Hughes W | | Unknown | Win |
| D1 | 09/04/1910 | Bolton Wanderers | 4-2 | Bristol City | Jones G, Hughes W 2, Stokes | | Unknown | Win |
| D1 | 02/04/1910 | Sheffield Wednesday | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 28/03/1910 | Notts County | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 26/03/1910 | Blackburn Rovers | 4-2 | Bolton Wanderers | Hughes W 2 | | Unknown | Loss |
| D1 | 19/03/1910 | Manchester United | 5-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 12/03/1910 | Bolton Wanderers | 0-1 | Everton | | | Unknown | Loss |
| D1 | 05/03/1910 | Sunderland | 3-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 26/02/1910 | Bolton Wanderers | 2-1 | Nottingham Forest | Hughes W, Barber | | Unknown | Win |
| D1 | 19/02/1910 | Bolton Wanderers | 1-1 | Bradford City | Jones G | | Unknown | Draw |
| D1 | 12/02/1910 | Bolton Wanderers | 5-2 | Chelsea | McEwan 2 (1 pen), Hunter 2, Lockett | | Unknown | Win |
| D1 | 05/02/1910 | Bolton Wanderers | 1-1 | Middlesbrough | Jones G | | Unknown | Draw |
| D1 | 29/01/1910 | Woolwich Arsenal | 2-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 22/01/1910 | Bolton Wanderers | 1-0 | Sheffield United | McEwan (pen) | | Unknown | Win |
| FAC1 | 15/01/1910 | Stockport County | 4-1 | Bolton Wanderers | Hogan | | Unknown | Loss |
| D1 | 08/01/1910 | Aston Villa | 3-1 | Bolton Wanderers | Hunter | | Unknown | Loss |
| D1 | 03/01/1910 | Bolton Wanderers | 0-2 | Sheffield Wednesday | | | Unknown | Loss |
| D1 | 01/01/1910 | Bolton Wanderers | 3-4 | Notts County | Jones G 2, Owen J | | Unknown | Loss |
| D1 | 25/12/1909 | Liverpool | 3-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 18/12/1909 | Bolton Wanderers | 3-1 | Preston North End | Hughes W, Baverstock H 2 (2 pens) | | Unknown | Win |
| D1 | 11/12/1909 | Tottenham Hotspur | 1-1 | Bolton Wanderers | Baverstock H (pen) | | Unknown | Draw |
| D1 | 04/12/1909 | Bolton Wanderers | 1-3 | Bury | Hunter | | Unknown | Loss |
| D1 | 27/11/1909 | Bristol City | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 13/11/1909 | Bradford City | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 06/11/1909 | Bolton Wanderers | 2-3 | Manchester United | Hunter, Lockett | | Unknown | Loss |
| D1 | 30/10/1909 | Everton | 3-1 | Bolton Wanderers | Lockett | | Unknown | Loss |
| D1 | 23/10/1909 | Bolton Wanderers | 2-1 | Sunderland | Lockett, Hunter | | Unknown | Win |
| D1 | 16/10/1909 | Nottingham Forest | 2-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 09/10/1909 | Bolton Wanderers | 1-2 | Blackburn Rovers | Hunter | | Unknown | Loss |
| D1 | 02/10/1909 | Chelsea | 3-2 | Bolton Wanderers | Hogan, Hunter | | Unknown | Loss |
| D1 | 25/09/1909 | Middlesbrough | 1-2 | Bolton Wanderers | Hughes W 2 | | Unknown | Win |
| D1 | 18/09/1909 | Bolton Wanderers | 3-0 | Woolwich Arsenal | Hunter, Hughes W, Marsh S | | Unknown | Win |
| D1 | 11/09/1909 | Sheffield United | 2-2 | Bolton Wanderers | Hughes W, Hunter | | Unknown | Draw |
| D1 | 07/09/1909 | Bolton Wanderers | 0-4 | Newcastle United | | | Unknown | Loss |
| D1 | 06/09/1909 | Bolton Wanderers | 1-2 | Liverpool | Hogan | | Unknown | Loss |
| D1 | 04/09/1909 | Bolton Wanderers | 1-2 | Aston Villa | Hughes W | | Unknown | Loss |
| D1 | 01/09/1909 | Newcastle United | 1-0 | Bolton Wanderers | | | Unknown | Loss |