| D1 | 30/04/1927 | Bolton Wanderers | 4-0 | Huddersfield Town | Wright W 3, Seddon J | | 21,229 | Win |
| D1 | 23/04/1927 | Blackburn Rovers | 0-3 | Bolton Wanderers | Vizard, Jack D, Gibson | | 14,816 | Win |
| D1 | 19/04/1927 | Sunderland | 6-2 | Bolton Wanderers | Gibson, Smith J R | | 14,316 | Loss |
| D1 | 18/04/1927 | Sheffield United | 1-1 | Bolton Wanderers | Blackmore | | 12,893 | Draw |
| D1 | 16/04/1927 | Bolton Wanderers | 5-0 | Everton | Smith J R, Gibson 3, Vizard | | 26,381 | Win |
| D1 | 15/04/1927 | Bolton Wanderers | 4-1 | Sheffield United | Gibson 2, Butler W, Jack D | | 23,149 | Win |
| D1 | 09/04/1927 | Leicester City | 0-1 | Bolton Wanderers | Blackmore | | 20,768 | Win |
| D1 | 04/04/1927 | Birmingham City | 6-1 | Bolton Wanderers | Gibson | | 6,321 | Loss |
| D1 | 02/04/1927 | Bolton Wanderers | 3-2 | Sheffield Wednesday | Blackmore, Marsden (og), Butler W | | 16,195 | Win |
| D1 | 26/03/1927 | West Ham United | 4-4 | Bolton Wanderers | Vizard, Jack D 2, Gibson | | 17,752 | Draw |
| D1 | 19/03/1927 | Bolton Wanderers | 2-2 | Tottenham Hotspur | Roberts W 2 | | 17,762 | Draw |
| D1 | 12/03/1927 | Bury | 2-0 | Bolton Wanderers | | | 30,532 | Loss |
| D1 | 09/03/1927 | Bolton Wanderers | 3-1 | Burnley | Jack D, Roberts W 2 | | 13,331 | Win |
| D1 | 05/03/1927 | Bolton Wanderers | 1-1 | West Bromwich Albion | Vizard | | 12,954 | Draw |
| D1 | 26/02/1927 | Manchester United | 0-0 | Bolton Wanderers | | | 29,618 | Draw |
| FAC5 | 19/02/1927 | Bolton Wanderers | 0-2 | Cardiff City | | | 49,465 | Loss |
| D1 | 12/02/1927 | Bolton Wanderers | 0-2 | Aston Villa | | | 17,745 | Loss |
| D1 | 05/02/1927 | Cardiff City | 1-0 | Bolton Wanderers | | | 12,721 | Loss |
| FAC4R | 02/02/1927 | Bolton Wanderers | 3-0 | Leeds United | Wright W, Jack D, Smith J R | | 46,686 | Win |
| FAC4 | 29/01/1927 | Leeds United | 0-0 | Bolton Wanderers | | Highlights | 42,694 | Draw |
| D1 | 22/01/1927 | Newcastle United | 1-0 | Bolton Wanderers | | | 57,431 | Loss |
| D1 | 15/01/1927 | Bolton Wanderers | 3-0 | Leeds United | Vizard, Jack D, Smith J R | | 19,149 | Win |
| FAC3 | 08/01/1927 | Blackpool | 1-3 | Bolton Wanderers | Smith J R 3 | | 16,297 | Win |
| D1 | 01/01/1927 | Bolton Wanderers | 2-1 | Liverpool | Smith J R 2 | | 34,513 | Win |
| D1 | 28/12/1926 | Liverpool | 3-2 | Bolton Wanderers | Smith J, Jack R R | | 14,802 | Loss |
| D1 | 27/12/1926 | Derby County | 2-0 | Bolton Wanderers | | | 30,557 | Loss |
| D1 | 25/12/1926 | Bolton Wanderers | 3-1 | Derby County | Butler W 3 (1 pen) | | 31,533 | Win |
| D1 | 18/12/1926 | Bolton Wanderers | 2-2 | Sunderland | Smith J 2 | | 24,232 | Draw |
| D1 | 11/12/1926 | Huddersfield Town | 1-0 | Bolton Wanderers | | | 24,667 | Loss |
| D1 | 04/12/1926 | Bolton Wanderers | 5-1 | Blackburn Rovers | Jack D, Butler W, Smith J, Vizard 2 | | 25,614 | Win |
| D1 | 27/11/1926 | Everton | 1-1 | Bolton Wanderers | Smith J R | | 28,091 | Draw |
| D1 | 20/11/1926 | Bolton Wanderers | 2-0 | Leicester City | Butler W, Jack D | | 15,255 | Win |
| D1 | 13/11/1926 | Sheffield Wednesday | 2-1 | Bolton Wanderers | Smith J | | 21,033 | Loss |
| D1 | 06/11/1926 | Bolton Wanderers | 2-0 | West Ham United | Jack D, Smith J | | 13,934 | Win |
| D1 | 30/10/1926 | Tottenham Hotspur | 1-0 | Bolton Wanderers | | | 29,999 | Loss |
| D1 | 23/10/1926 | Bolton Wanderers | 2-2 | Bury | Butler W, Wright W | | 39,258 | Draw |
| D1 | 16/10/1926 | West Bromwich Albion | 1-1 | Bolton Wanderers | Wright W | | 16,622 | Draw |
| D1 | 09/10/1926 | Bolton Wanderers | 4-0 | Manchester United | Smith J R, Wright W 2, Butler W | | 17,869 | Win |
| D1 | 02/10/1926 | Bolton Wanderers | 1-0 | Birmingham City | Jack D (pen) | | 20,006 | Win |
| D1 | 25/09/1926 | Aston Villa | 3-4 | Bolton Wanderers | Vizard, Jakeman (og), Jack D, Smith J R | | 20,696 | Win |
| D1 | 18/09/1926 | Bolton Wanderers | 2-0 | Cardiff City | Vizard, Jack D | | 18,737 | Win |
| D1 | 11/09/1926 | Burnley | 4-3 | Bolton Wanderers | Baggett 2, Jack D | | 23,730 | Loss |
| D1 | 06/09/1926 | Bolton Wanderers | 2-2 | Arsenal | Smith J R, Jack D | | 19,717 | Draw |
| D1 | 04/09/1926 | Bolton Wanderers | 2-1 | Newcastle United | Jack D, Smith J R | | 25,049 | Win |
| D1 | 01/09/1926 | Arsenal | 2-1 | Bolton Wanderers | Butler W | | 23,002 | Loss |
| D1 | 28/08/1926 | Leeds United | 2-5 | Bolton Wanderers | Smith J (pen), Jack D, Smith J R 3 | | 23,699 | Win |