| D1 | 07/05/1949 | Bolton Wanderers | 1-0 | Everton | Moir | | 22,725 | Win |
| D1 | 04/05/1949 | Bolton Wanderers | 1-1 | Chelsea | Roberts J | | 19,084 | Draw |
| D1 | 30/04/1949 | Preston North End | 1-1 | Bolton Wanderers | Lofthouse | | 33,495 | Draw |
| D1 | 23/04/1949 | Bolton Wanderers | 1-2 | Portsmouth | Roberts J | | 31,063 | Loss |
| D1 | 18/04/1949 | Manchester United | 3-0 | Bolton Wanderers | | | 50,504 | Loss |
| D1 | 16/04/1949 | Newcastle United | 1-1 | Bolton Wanderers | Moir | | 39,999 | Draw |
| D1 | 15/04/1949 | Bolton Wanderers | 0-1 | Manchester United | | | 47,157 | Loss |
| D1 | 09/04/1949 | Bolton Wanderers | 2-2 | Charlton Athletic | Bradley J 2 | | 20,371 | Draw |
| D1 | 02/04/1949 | Manchester City | 1-0 | Bolton Wanderers | | | 27,241 | Loss |
| D1 | 26/03/1949 | Bolton Wanderers | 0-1 | Burnley | | | 26,593 | Loss |
| D1 | 19/03/1949 | Stoke City | 4-0 | Bolton Wanderers | | | 24,350 | Loss |
| D1 | 12/03/1949 | Bolton Wanderers | 4-1 | Middlesbrough | Moir 3 (1 pen), Lofthouse | | 28,783 | Win |
| D1 | 05/03/1949 | Birmingham City | 0-0 | Bolton Wanderers | | | 20,730 | Draw |
| D1 | 26/02/1949 | Arsenal | 5-0 | Bolton Wanderers | | | 50,263 | Loss |
| D1 | 19/02/1949 | Bolton Wanderers | 4-0 | Derby County | Woodward, Moir, Lofthouse, Bradley J | | 37,948 | Win |
| D1 | 12/02/1949 | Blackpool | 1-0 | Bolton Wanderers | | | 23,210 | Loss |
| D1 | 22/01/1949 | Bolton Wanderers | 0-3 | Liverpool | | | 35,668 | Loss |
| FAC3R2 | 17/01/1949 | Aston Villa | 2-1 | Bolton Wanderers | Lofthouse (aet) | | 49,709 | Loss |
| FAC3R | 15/01/1949 | Bolton Wanderers | 0-0 | Aston Villa | (aet) | | 38,706 | Draw |
| FAC3 | 08/01/1949 | Aston Villa | 1-1 | Bolton Wanderers | Bradley J (aet) | | 53,459 | Draw |
| D1 | 01/01/1949 | Wolverhampton Wanderers | 2-0 | Bolton Wanderers | | | 27,110 | Loss |
| D1 | 27/12/1948 | Bolton Wanderers | 6-1 | Sheffield United | Moir 4, Lofthouse 2 | | 42,630 | Win |
| D1 | 25/12/1948 | Sheffield United | 1-1 | Bolton Wanderers | Bradley J | | 39,676 | Draw |
| D1 | 18/12/1948 | Bolton Wanderers | 4-1 | Sunderland | Moir, Lofthouse 2, Bradley J | | 24,309 | Win |
| D1 | 11/12/1948 | Everton | 1-0 | Bolton Wanderers | | | 40,407 | Loss |
| D1 | 04/12/1948 | Bolton Wanderers | 5-3 | Preston North End | Bradley J 2, Moir 2, Barrass | | 40,140 | Win |
| D1 | 27/11/1948 | Burnley | 3-0 | Bolton Wanderers | | | 37,291 | Loss |
| D1 | 20/11/1948 | Bolton Wanderers | 2-1 | Stoke City | Moir, Barrass | | 37,249 | Win |
| D1 | 13/11/1948 | Charlton Athletic | 1-4 | Bolton Wanderers | Barrass, Moir 2, Woodward | | 37,047 | Win |
| D1 | 06/11/1948 | Bolton Wanderers | 5-1 | Manchester City | Moir, Barrass 4 (1 pen) | | 40,089 | Win |
| D1 | 30/10/1948 | Portsmouth | 0-0 | Bolton Wanderers | | | 29,760 | Draw |
| D1 | 23/10/1948 | Bolton Wanderers | 1-5 | Newcastle United | Moir | | 39,071 | Loss |
| D1 | 16/10/1948 | Middlesbrough | 5-0 | Bolton Wanderers | | | 28,628 | Loss |
| D1 | 09/10/1948 | Bolton Wanderers | 0-0 | Birmingham City | | | 45,494 | Draw |
| D1 | 02/10/1948 | Bolton Wanderers | 1-0 | Arsenal | Howe | | 45,228 | Win |
| D1 | 25/09/1948 | Derby County | 1-0 | Bolton Wanderers | | | 33,972 | Loss |
| D1 | 18/09/1948 | Bolton Wanderers | 2-2 | Blackpool | Moir, Hernon | | 46,779 | Draw |
| D1 | 15/09/1948 | Huddersfield Town | 0-2 | Bolton Wanderers | Moir 2 | | 16,046 | Win |
| D1 | 11/09/1948 | Liverpool | 0-1 | Bolton Wanderers | McShane | | 56,561 | Win |
| D1 | 06/09/1948 | Bolton Wanderers | 1-2 | Huddersfield Town | Jackson J | | 25,332 | Loss |
| D1 | 04/09/1948 | Chelsea | 2-2 | Bolton Wanderers | Howe (pen), McShane | | 42,971 | Draw |
| D1 | 30/08/1948 | Aston Villa | 2-4 | Bolton Wanderers | Moir 4 (1 pen) | | 26,890 | Win |
| D1 | 28/08/1948 | Bolton Wanderers | 0-5 | Wolverhampton Wanderers | | | 35,878 | Loss |
| D1 | 25/08/1948 | Bolton Wanderers | 3-0 | Aston Villa | Bradley J, Dillon 2 | | 24,774 | Win |
| D1 | 21/08/1948 | Sunderland | 2-0 | Bolton Wanderers | | | 47,854 | Loss |