| FACF | 02/05/1953 | Bolton Wanderers | 3-4 | Blackpool | Moir, Bell E, Lofthouse (played at Wembley Stadium) | Highlights | 100,000 | Loss |
| D1 | 25/04/1953 | Newcastle United | 2-3 | Bolton Wanderers | Lofthouse 3 (1 pen) | | 34,824 | Win |
| D1 | 22/04/1953 | Bolton Wanderers | 0-1 | West Bromwich Albion | | | 17,189 | Loss |
| D1 | 18/04/1953 | Bolton Wanderers | 0-1 | Cardiff City | | | 18,037 | Loss |
| D1 | 15/04/1953 | Arsenal | 4-1 | Bolton Wanderers | Moir | | 35,381 | Loss |
| D1 | 11/04/1953 | Sheffield Wednesday | 1-1 | Bolton Wanderers | Lofthouse | | 39,893 | Draw |
| D1 | 06/04/1953 | Sunderland | 2-0 | Bolton Wanderers | | | 32,227 | Loss |
| D1 | 04/04/1953 | Bolton Wanderers | 2-3 | Tottenham Hotspur | Moir 2 | | 40,185 | Loss |
| D1 | 03/04/1953 | Bolton Wanderers | 5-0 | Sunderland | Lofthouse 3 (1 pen), Langton, Neill | | 34,862 | Win |
| D1 | 28/03/1953 | Burnley | 0-1 | Bolton Wanderers | Moir | | 20,392 | Win |
| D1 | 25/03/1953 | Bolton Wanderers | 0-3 | Preston North End | | | 22,173 | Loss |
| FACSF | 21/03/1953 | Bolton Wanderers | 4-3 | Everton | Moir, Lofthouse 2, Holden D (played at Maine Road, Manchester) | Highlights | 75,000 | Win |
| D1 | 14/03/1953 | Stoke City | 1-2 | Bolton Wanderers | Lofthouse, Webster | | 28,070 | Win |
| D1 | 11/03/1953 | Cardiff City | 1-0 | Bolton Wanderers | | | 31,099 | Loss |
| D1 | 07/03/1953 | Bolton Wanderers | 1-0 | Manchester City | Lofthouse | | 39,585 | Win |
| D1 | 04/03/1953 | Liverpool | 0-0 | Bolton Wanderers | | | 24,999 | Draw |
| FACQF | 28/02/1953 | Gateshead | 0-1 | Bolton Wanderers | Lofthouse | Highlights | 17,692 | Win |
| D1 | 21/02/1953 | Bolton Wanderers | 0-0 | Aston Villa | | | 34,446 | Draw |
| D1 | 18/02/1953 | Bolton Wanderers | 5-3 | Middlesbrough | Lofthouse 3, Hassall, Hughes W | | 15,041 | Win |
| FAC5 | 16/02/1953 | Luton Town | 0-1 | Bolton Wanderers | Lofthouse | | 23,735 | Win |
| FAC4R2 | 09/02/1953 | Bolton Wanderers | 1-0 | Notts County | Lofthouse (played at Hillsborough, Sheffield) | | 23,171 | Win |
| D1 | 07/02/1953 | Portsmouth | 3-1 | Bolton Wanderers | Parry R | | 25,240 | Loss |
| FAC4R | 05/02/1953 | Notts County | 2-2 | Bolton Wanderers | Moir 2 (aet) | | 33,668 | Draw |
| FAC4 | 31/01/1953 | Bolton Wanderers | 1-1 | Notts County | Lofthouse | | 40,048 | Draw |
| D1 | 24/01/1953 | Bolton Wanderers | 2-1 | Manchester United | Moir 2 | | 46,818 | Win |
| D1 | 17/01/1953 | Chelsea | 1-0 | Bolton Wanderers | | | 36,572 | Loss |
| FAC3 | 14/01/1953 | Bolton Wanderers | 3-1 | Fulham | Holden D, Moir, Lofthouse | | 32,235 | Win |
| D1 | 03/01/1953 | Bolton Wanderers | 4-0 | Blackpool | Wheeler 3, Moir | | 36,572 | Win |
| D1 | 01/01/1953 | Bolton Wanderers | 1-2 | Charlton Athletic | Holden D | | 32,614 | Loss |
| D1 | 25/12/1952 | Bolton Wanderers | 4-6 | Arsenal | Moir 2, Lofthouse 2 | | 45,432 | Loss |
| D1 | 20/12/1952 | Derby County | 4-3 | Bolton Wanderers | Moir, Lofthouse, Hassall | | 12,884 | Loss |
| D1 | 13/12/1952 | West Bromwich Albion | 0-1 | Bolton Wanderers | Beards | | 16,148 | Win |
| D1 | 06/12/1952 | Bolton Wanderers | 4-2 | Newcastle United | Moir, Lofthouse, Hassall 2 | | 28,577 | Win |
| D1 | 22/11/1952 | Bolton Wanderers | 1-1 | Sheffield Wednesday | Moir | | 34,435 | Draw |
| D1 | 15/11/1952 | Tottenham Hotspur | 1-1 | Bolton Wanderers | Lofthouse | | 31,442 | Draw |
| D1 | 08/11/1952 | Bolton Wanderers | 1-2 | Burnley | Lofthouse | | 37,603 | Loss |
| D1 | 01/11/1952 | Preston North End | 2-2 | Bolton Wanderers | Hassall, Langton (pen) | | 37,848 | Draw |
| D1 | 25/10/1952 | Bolton Wanderers | 2-1 | Stoke City | Moir 2 | | 28,295 | Win |
| D1 | 18/10/1952 | Manchester City | 1-2 | Bolton Wanderers | Lofthouse, Langton | | 42,369 | Win |
| D1 | 11/10/1952 | Bolton Wanderers | 2-2 | Liverpool | Lofthouse 2 | | 38,450 | Draw |
| D1 | 04/10/1952 | Aston Villa | 1-1 | Bolton Wanderers | Beards | | 32,242 | Draw |
| D1 | 27/09/1952 | Middlesbrough | 1-2 | Bolton Wanderers | Moir, Hassall | | 26,679 | Win |
| D1 | 20/09/1952 | Bolton Wanderers | 0-5 | Portsmouth | | | 29,590 | Loss |
| D1 | 13/09/1952 | Manchester United | 1-0 | Bolton Wanderers | | | 42,370 | Loss |
| D1 | 10/09/1952 | Charlton Athletic | 2-0 | Bolton Wanderers | | | 14,900 | Loss |
| D1 | 06/09/1952 | Bolton Wanderers | 1-1 | Chelsea | Lofthouse | | 29,877 | Draw |
| D1 | 01/09/1952 | Bolton Wanderers | 2-1 | Wolverhampton Wanderers | Moir, Hassall | | 28,057 | Win |
| D1 | 30/08/1952 | Blackpool | 3-0 | Bolton Wanderers | | | 31,317 | Loss |
| D1 | 25/08/1952 | Wolverhampton Wanderers | 3-1 | Bolton Wanderers | Moir | | 32,449 | Loss |
| D1 | 23/08/1952 | Bolton Wanderers | 2-0 | Derby County | Holden D, Langton | | 35,551 | Win |