| D1 | 05/05/1951 | Chelsea | 4-0 | Bolton Wanderers | | | 38,928 | Loss |
| D1 | 28/04/1951 | Bolton Wanderers | 2-1 | Wolverhampton Wanderers | Moir, Codd | | 26,775 | Win |
| D1 | 21/04/1951 | Arsenal | 1-1 | Bolton Wanderers | Lofthouse | | 42,040 | Draw |
| D1 | 18/04/1951 | Newcastle United | 0-1 | Bolton Wanderers | Lofthouse | | 39,099 | Win |
| D1 | 14/04/1951 | Bolton Wanderers | 0-1 | Sheffield Wednesday | | | 19,956 | Loss |
| D1 | 07/04/1951 | Middlesbrough | 1-1 | Bolton Wanderers | Moir | | 24,423 | Draw |
| D1 | 31/03/1951 | Bolton Wanderers | 0-2 | West Bromwich Albion | | | 21,860 | Loss |
| D1 | 26/03/1951 | Bolton Wanderers | 1-2 | Blackpool | Langton | | 42,265 | Loss |
| D1 | 24/03/1951 | Stoke City | 2-1 | Bolton Wanderers | Lofthouse | | 20,682 | Loss |
| D1 | 23/03/1951 | Blackpool | 2-0 | Bolton Wanderers | | | 33,627 | Loss |
| D1 | 17/03/1951 | Bolton Wanderers | 4-0 | Huddersfield Town | Lofthouse, Langton (pen), Webster, Wheeler | | 29,796 | Win |
| D1 | 03/03/1951 | Bolton Wanderers | 2-0 | Everton | Codd, Langton | | 36,752 | Win |
| D1 | 24/02/1951 | Portsmouth | 2-1 | Bolton Wanderers | Lofthouse | | 27,222 | Loss |
| D1 | 17/02/1951 | Bolton Wanderers | 2-1 | Liverpool | Howe, Lofthouse | | 34,807 | Win |
| D1 | 10/02/1951 | Bolton Wanderers | 1-1 | Burnley | Howe (pen) | | 35,540 | Draw |
| D1 | 03/02/1951 | Derby County | 2-2 | Bolton Wanderers | Lofthouse, Webster | | 19,879 | Draw |
| FAC4 | 27/01/1951 | Newcastle United | 3-2 | Bolton Wanderers | Moir 2 | | 68,659 | Loss |
| D1 | 20/01/1951 | Bolton Wanderers | 1-0 | Aston Villa | Moss (og) | | 29,233 | Win |
| D1 | 13/01/1951 | Sunderland | 1-2 | Bolton Wanderers | Moir, Webster | | 47,197 | Win |
| FAC3 | 06/01/1951 | Bolton Wanderers | 2-0 | York City | Lofthouse, Langton | | 26,652 | Win |
| D1 | 26/12/1950 | Bolton Wanderers | 0-1 | Fulham | | | 43,116 | Loss |
| D1 | 25/12/1950 | Fulham | 0-1 | Bolton Wanderers | Lofthouse | | 21,712 | Win |
| D1 | 23/12/1950 | Manchester United | 2-3 | Bolton Wanderers | Lofthouse 2, Webster | | 37,235 | Win |
| D1 | 16/12/1950 | Bolton Wanderers | 3-0 | Charlton Athletic | Moir, Langton 2 | | 19,207 | Win |
| D1 | 09/12/1950 | Burnley | 2-0 | Bolton Wanderers | | | 31,124 | Loss |
| D1 | 02/12/1950 | Bolton Wanderers | 3-0 | Arsenal | Moir, Langton 2 | | 43,484 | Win |
| D1 | 25/11/1950 | Sheffield Wednesday | 3-4 | Bolton Wanderers | Lofthouse 2, Webster 2 | | 37,053 | Win |
| D1 | 18/11/1950 | Bolton Wanderers | 0-2 | Middlesbrough | | | 37,296 | Loss |
| D1 | 11/11/1950 | West Bromwich Albion | 0-1 | Bolton Wanderers | Kennedy (og) | | 28,816 | Win |
| D1 | 04/11/1950 | Bolton Wanderers | 1-1 | Stoke City | Webster | | 34,244 | Draw |
| D1 | 28/10/1950 | Huddersfield Town | 0-4 | Bolton Wanderers | Howe (pen), Moir, Lofthouse, Webster | | 30,989 | Win |
| D1 | 21/10/1950 | Bolton Wanderers | 0-2 | Newcastle United | | | 49,213 | Loss |
| D1 | 14/10/1950 | Everton | 1-1 | Bolton Wanderers | Moir | | 53,421 | Draw |
| D1 | 07/10/1950 | Bolton Wanderers | 4-0 | Portsmouth | Lofthouse 2, Webster 2 | | 36,995 | Win |
| D1 | 30/09/1950 | Liverpool | 3-3 | Bolton Wanderers | Moir, Lofthouse, Webster | | 44,534 | Draw |
| D1 | 23/09/1950 | Bolton Wanderers | 3-0 | Derby County | Howe (pen), Lofthouse, Webster | | 36,745 | Win |
| D1 | 16/09/1950 | Aston Villa | 0-1 | Bolton Wanderers | Moir | | 32,817 | Win |
| D1 | 09/09/1950 | Bolton Wanderers | 1-2 | Sunderland | Webster | | 30,745 | Loss |
| D1 | 04/09/1950 | Bolton Wanderers | 1-0 | Chelsea | Hughes W | | 25,457 | Win |
| D1 | 02/09/1950 | Wolverhampton Wanderers | 7-1 | Bolton Wanderers | Moir | | 46,764 | Loss |
| D1 | 28/08/1950 | Tottenham Hotspur | 4-2 | Bolton Wanderers | Moir 2 | | 44,246 | Loss |
| D1 | 26/08/1950 | Bolton Wanderers | 1-0 | Manchester United | Lofthouse | | 40,759 | Win |
| D1 | 23/08/1950 | Bolton Wanderers | 1-4 | Tottenham Hotspur | Langton | | 21,745 | Loss |
| D1 | 19/08/1950 | Charlton Athletic | 4-3 | Bolton Wanderers | Lofthouse 3 | | 30,487 | Loss |