| D1 | 05/05/1928 | Bolton Wanderers | 1-1 | Sheffield United | McClelland | | 7,958 | Draw |
| D1 | 28/04/1928 | Aston Villa | 2-2 | Bolton Wanderers | Gibson, Boston | | 22,895 | Draw |
| D1 | 21/04/1928 | Bolton Wanderers | 4-0 | West Ham United | McClelland, Murphy L, Butler W, Nuttall | | 8,520 | Win |
| D1 | 14/04/1928 | Derby County | 1-0 | Bolton Wanderers | | | 12,378 | Loss |
| D1 | 09/04/1928 | Manchester United | 2-1 | Bolton Wanderers | McClelland | | 28,590 | Loss |
| D1 | 07/04/1928 | Bolton Wanderers | 1-2 | Sunderland | McClelland (pen) | | 18,064 | Loss |
| D1 | 06/04/1928 | Bolton Wanderers | 3-2 | Manchester United | McClelland, Vizard, Round | | 23,795 | Win |
| D1 | 31/03/1928 | Portsmouth | 1-0 | Bolton Wanderers | | | 21,846 | Loss |
| D1 | 24/03/1928 | Bolton Wanderers | 3-3 | Leicester City | McClelland 2, Butler W | | 18,142 | Draw |
| D1 | 17/03/1928 | Burnley | 2-2 | Bolton Wanderers | Butler W, McClelland | | 15,865 | Draw |
| D1 | 10/03/1928 | Bolton Wanderers | 1-1 | Arsenal | Jack R R | | 15,546 | Draw |
| D1 | 03/03/1928 | Liverpool | 4-2 | Bolton Wanderers | Jack D, Gibson | | 37,115 | Loss |
| D1 | 29/02/1928 | Bolton Wanderers | 2-0 | Sheffield Wednesday | Jack D 2 | | 9,786 | Win |
| D1 | 25/02/1928 | Bolton Wanderers | 0-1 | Huddersfield Town | | | 44,082 | Loss |
| D1 | 18/02/1928 | Newcastle United | 2-2 | Bolton Wanderers | Jack D, Murphy L | | 28,932 | Draw |
| D1 | 11/02/1928 | Bolton Wanderers | 3-2 | Birmingham City | Jack D 2, Gibson | | 11,747 | Win |
| D1 | 06/02/1928 | Tottenham Hotspur | 1-2 | Bolton Wanderers | Smith J R 2 | | 18,183 | Win |
| D1 | 04/02/1928 | Middlesbrough | 2-5 | Bolton Wanderers | Jack D 2, Smith J R, Butler W, Murphy L | | 21,109 | Win |
| FAC4 | 28/01/1928 | Stoke City | 4-2 | Bolton Wanderers | Round, Murphy L | | 25,000 | Loss |
| D1 | 21/01/1928 | Bolton Wanderers | 2-1 | Bury | Jack D, Smith J R | | 32,497 | Win |
| FAC3 | 14/01/1928 | Bolton Wanderers | 2-1 | Luton Town | Butler W, Smith J R | | 20,266 | Win |
| D1 | 07/01/1928 | Blackburn Rovers | 1-6 | Bolton Wanderers | Jack D 2, Gibson 2, Smith J R 2 | | 14,660 | Win |
| D1 | 02/01/1928 | Bolton Wanderers | 1-3 | Derby County | Gibson | | 23,569 | Loss |
| D1 | 31/12/1927 | Bolton Wanderers | 2-1 | Cardiff City | Jack D, Blackmore | | 15,745 | Win |
| D1 | 26/12/1927 | Bolton Wanderers | 4-1 | Tottenham Hotspur | Jack D 2, Nuttall, Gibson | | 25,229 | Win |
| D1 | 24/12/1927 | Sheffield United | 4-3 | Bolton Wanderers | Jack D 3 | | 10,503 | Loss |
| D1 | 17/12/1927 | Bolton Wanderers | 3-1 | Aston Villa | Finney, Smith J R, Vizard | | 14,852 | Win |
| D1 | 10/12/1927 | West Ham United | 2-0 | Bolton Wanderers | | | 18,926 | Loss |
| D1 | 26/11/1927 | Sunderland | 1-1 | Bolton Wanderers | Jack D | | 20,406 | Draw |
| D1 | 19/11/1927 | Bolton Wanderers | 3-1 | Portsmouth | Jack D, Wright W, Blackmore | | 14,302 | Win |
| D1 | 12/11/1927 | Leicester City | 4-2 | Bolton Wanderers | Wright W, Blackmore | | 21,249 | Loss |
| D1 | 05/11/1927 | Bolton Wanderers | 7-1 | Burnley | Blackmore 4 (1 pen), Jack D 3 | | 14,340 | Win |
| D1 | 29/10/1927 | Arsenal | 1-2 | Bolton Wanderers | Gibson, Vizard | | 35,787 | Win |
| D1 | 22/10/1927 | Bolton Wanderers | 2-1 | Liverpool | Vizard, Blackmore | | 12,024 | Win |
| D1 | 15/10/1927 | Huddersfield Town | 1-0 | Bolton Wanderers | | | 19,818 | Loss |
| D1 | 08/10/1927 | Bolton Wanderers | 1-2 | Newcastle United | Jack D | | 30,676 | Loss |
| D1 | 01/10/1927 | Birmingham City | 1-1 | Bolton Wanderers | Jack D | | 15,988 | Draw |
| D1 | 24/09/1927 | Bolton Wanderers | 0-0 | Middlesbrough | | | 21,720 | Draw |
| D1 | 17/09/1927 | Sheffield Wednesday | 3-0 | Bolton Wanderers | | | 19,111 | Loss |
| D1 | 14/09/1927 | Everton | 2-2 | Bolton Wanderers | Butler W, Picken A | | 22,726 | Draw |
| D1 | 10/09/1927 | Bury | 1-0 | Bolton Wanderers | | | 24,593 | Loss |
| D1 | 05/09/1927 | Bolton Wanderers | 1-1 | Everton | Jack R R | | 18,734 | Draw |
| D1 | 03/09/1927 | Bolton Wanderers | 3-1 | Blackburn Rovers | Smith J R 2, Picken A | | 25,711 | Win |
| D1 | 27/08/1927 | Cardiff City | 2-1 | Bolton Wanderers | Smith J R | | 24,107 | Loss |