| PL | 22/05/2011 | Bolton Wanderers | 0-2 | Manchester City | | | 26,285 | Loss |
| PL | 14/05/2011 | Blackpool | 4-3 | Bolton Wanderers | Davies K, Taylor, Sturridge | | 15,979 | Loss |
| PL | 07/05/2011 | Bolton Wanderers | 1-2 | Sunderland | Klasnic | | 22,597 | Loss |
| PL | 30/04/2011 | Blackburn Rovers | 1-0 | Bolton Wanderers | | | 28,985 | Loss |
| PL | 27/04/2011 | Fulham | 3-0 | Bolton Wanderers | | | 23,222 | Loss |
| PL | 24/04/2011 | Bolton Wanderers | 2-1 | Arsenal | Sturridge, Cohen | | 26,881 | Win |
| FACSF | 17/04/2011 | Bolton Wanderers | 0-5 | Stoke City | (played at Wembley Stadium) | Highlights | 75,064 | Loss |
| PL | 09/04/2011 | Bolton Wanderers | 3-0 | West Ham United | Sturridge 2, Chung-Yong | | 25,857 | Win |
| PL | 02/04/2011 | Birmingham City | 2-1 | Bolton Wanderers | Elmander | | 26,142 | Loss |
| PL | 19/03/2011 | Manchester United | 1-0 | Bolton Wanderers | | | 75,486 | Loss |
| FACQF | 12/03/2011 | Birmingham City | 2-3 | Bolton Wanderers | Elmander, Davies K (pen), Chung-Yong | Highlights | 23,699 | Win |
| PL | 05/03/2011 | Bolton Wanderers | 3-2 | Aston Villa | Cahill 2, Klasnic | | 22,533 | Win |
| PL | 26/02/2011 | Newcastle United | 1-1 | Bolton Wanderers | Sturridge | | 48,062 | Draw |
| FAC5 | 20/02/2011 | Fulham | 0-1 | Bolton Wanderers | Klasnic | Highlights | 19,571 | Win |
| FAC4R | 16/02/2011 | Wigan Athletic | 0-1 | Bolton Wanderers | Klasnic | Highlights | 7,515 | Win |
| PL | 13/02/2011 | Bolton Wanderers | 2-0 | Everton | Cahill, Sturridge | | 22,986 | Win |
| PL | 05/02/2011 | Tottenham Hotspur | 2-1 | Bolton Wanderers | Sturridge | | 36,197 | Loss |
| PL | 02/02/2011 | Bolton Wanderers | 1-0 | Wolverhampton Wanderers | Sturridge | | 18,944 | Win |
| FAC4 | 29/01/2011 | Bolton Wanderers | 0-0 | Wigan Athletic | | Highlights | 14,950 | Draw |
| PL | 24/01/2011 | Bolton Wanderers | 0-4 | Chelsea | | | 22,837 | Loss |
| PL | 15/01/2011 | Stoke City | 2-0 | Bolton Wanderers | | | 26,809 | Loss |
| FAC3 | 08/01/2011 | Bolton Wanderers | 2-0 | York City | Davies K, Elmander | Highlights | 13,120 | Win |
| PL | 05/01/2011 | Bolton Wanderers | 1-1 | Wigan Athletic | Rodrigo | | 18,852 | Draw |
| PL | 01/01/2011 | Liverpool | 2-1 | Bolton Wanderers | Davies K | | 35,400 | Loss |
| PL | 29/12/2010 | Chelsea | 1-0 | Bolton Wanderers | | | 40,982 | Loss |
| PL | 26/12/2010 | Bolton Wanderers | 2-0 | West Bromwich Albion | Taylor, Elmander | | 23,413 | Win |
| PL | 18/12/2010 | Sunderland | 1-0 | Bolton Wanderers | | | 35,101 | Loss |
| PL | 12/12/2010 | Bolton Wanderers | 2-1 | Blackburn Rovers | Muamba, Holden | | 24,471 | Win |
| PL | 04/12/2010 | Manchester City | 1-0 | Bolton Wanderers | | | 46,860 | Loss |
| PL | 27/11/2010 | Bolton Wanderers | 2-2 | Blackpool | Petrov, Davies M | | 25,851 | Draw |
| PL | 20/11/2010 | Bolton Wanderers | 5-1 | Newcastle United | Davies K 2 (2 pens), Chung-Yong, Elmander 2 | | 22,203 | Win |
| PL | 13/11/2010 | Wolverhampton Wanderers | 2-3 | Bolton Wanderers | Stearman (og), Elmander, Holden | | 27,508 | Win |
| PL | 10/11/2010 | Everton | 1-1 | Bolton Wanderers | Klasnic | | 31,808 | Draw |
| PL | 06/11/2010 | Bolton Wanderers | 4-2 | Tottenham Hotspur | Davies K 2 (1 pen), Steinsson, Petrov | | 20,255 | Win |
| PL | 31/10/2010 | Bolton Wanderers | 0-1 | Liverpool | | | 25,171 | Loss |
| PL | 23/10/2010 | Wigan Athletic | 1-1 | Bolton Wanderers | Elmander | | 17,100 | Draw |
| PL | 16/10/2010 | Bolton Wanderers | 2-1 | Stoke City | Chung-Yong, Klasnic | | 22,975 | Win |
| PL | 02/10/2010 | West Bromwich Albion | 1-1 | Bolton Wanderers | Elmander | | 22,846 | Draw |
| PL | 26/09/2010 | Bolton Wanderers | 2-2 | Manchester United | Knight, Petrov | | 23,926 | Draw |
| LC3 | 21/09/2010 | Burnley | 1-0 | Bolton Wanderers | | | 17,602 | Loss |
| PL | 18/09/2010 | Aston Villa | 1-1 | Bolton Wanderers | Davies K | | 34,655 | Draw |
| PL | 11/09/2010 | Arsenal | 4-1 | Bolton Wanderers | Elmander | | 59,876 | Loss |
| PL | 29/08/2010 | Bolton Wanderers | 2-2 | Birmingham City | Davies K (pen), Blake | | 18,139 | Draw |
| LC2 | 24/08/2010 | Southampton | 0-1 | Bolton Wanderers | Klasnic | | 10,251 | Win |
| PL | 21/08/2010 | West Ham United | 1-3 | Bolton Wanderers | Upson (og), Elmander 2 | | 32,533 | Win |
| PL | 14/08/2010 | Bolton Wanderers | 0-0 | Fulham | | | 20,352 | Draw |