| D1 | 29/04/1961 | Bolton Wanderers | 1-1 | Preston North End | Stevens D | | 12,637 | Draw |
| D1 | 22/04/1961 | Newcastle United | 4-1 | Bolton Wanderers | Pilkington | | 18,820 | Loss |
| D1 | 18/04/1961 | Preston North End | 0-0 | Bolton Wanderers | | | 17,786 | Draw |
| D1 | 15/04/1961 | Bolton Wanderers | 3-1 | Nottingham Forest | Hartle, Birch, Hill | | 18,601 | Win |
| D1 | 08/04/1961 | Burnley | 2-0 | Bolton Wanderers | | | 22,998 | Loss |
| D1 | 04/04/1961 | Aston Villa | 4-0 | Bolton Wanderers | | | 15,732 | Loss |
| D1 | 03/04/1961 | Bolton Wanderers | 3-0 | Aston Villa | McAdams 3 (1 pen) | | 21,721 | Win |
| D1 | 01/04/1961 | Bolton Wanderers | 1-1 | Arsenal | Neill (og) | | 18,618 | Draw |
| D1 | 25/03/1961 | Manchester City | 0-0 | Bolton Wanderers | | | 21,816 | Draw |
| D1 | 18/03/1961 | Bolton Wanderers | 0-1 | Sheffield Wednesday | | | 19,418 | Loss |
| D1 | 11/03/1961 | Fulham | 2-2 | Bolton Wanderers | Holden D, Phythian | | 18,794 | Draw |
| D1 | 04/03/1961 | Bolton Wanderers | 3-0 | Cardiff City | Holden D, Stevens D 2 | | 21,815 | Win |
| D1 | 25/02/1961 | West Bromwich Albion | 3-2 | Bolton Wanderers | Stevens D, Bannister N | | 15,171 | Loss |
| D1 | 18/02/1961 | Manchester United | 3-1 | Bolton Wanderers | McAdams | | 38,146 | Loss |
| D1 | 11/02/1961 | Bolton Wanderers | 0-0 | Blackburn Rovers | | | 16,183 | Draw |
| D1 | 04/02/1961 | Everton | 1-2 | Bolton Wanderers | McAdams 2 (1 pen) | | 35,654 | Win |
| FAC4R | 01/02/1961 | Blackburn Rovers | 4-0 | Bolton Wanderers | | | 31,000 | Loss |
| FAC4 | 28/01/1961 | Bolton Wanderers | 3-3 | Blackburn Rovers | Stanley G (pen), McAdams, Stevens D | | 29,804 | Draw |
| D1 | 21/01/1961 | Bolton Wanderers | 3-1 | Blackpool | McAdams, Stanley G (pen), Stevens D | | 15,909 | Win |
| D1 | 14/01/1961 | Chelsea | 1-1 | Bolton Wanderers | McAdams | | 20,461 | Draw |
| FAC3 | 07/01/1961 | Hull City | 0-1 | Bolton Wanderers | Stevens D | | 18,771 | Win |
| D1 | 31/12/1960 | Bolton Wanderers | 3-1 | West Ham United | Birch, McAdams, Stevens D | | 15,931 | Win |
| D1 | 26/12/1960 | Leicester City | 2-0 | Bolton Wanderers | | | 23,806 | Loss |
| D1 | 24/12/1960 | Bolton Wanderers | 2-0 | Leicester City | Deakin P, Stevens D | | 11,534 | Win |
| LC4 | 20/12/1960 | Bolton Wanderers | 0-2 | Rotherham United | | | 6,594 | Loss |
| D1 | 17/12/1960 | Birmingham City | 2-2 | Bolton Wanderers | Stevens D 2 | | 19,051 | Draw |
| D1 | 10/12/1960 | Arsenal | 5-1 | Bolton Wanderers | McAdams | | 30,598 | Loss |
| D1 | 03/12/1960 | Bolton Wanderers | 2-1 | Newcastle United | Edwards M, Stevens D | | 12,921 | Win |
| D1 | 19/11/1960 | Bolton Wanderers | 3-5 | Burnley | McAdams 2, Lee F | | 23,830 | Loss |
| LC3 | 14/11/1960 | Darlington | 1-2 | Bolton Wanderers | Hartle, Holden D | | 21,023 | Win |
| D1 | 12/11/1960 | Nottingham Forest | 2-2 | Bolton Wanderers | Lofthouse, Iley (og) | | 18,812 | Draw |
| D1 | 05/11/1960 | Bolton Wanderers | 3-1 | Manchester City | Stanley G, Lofthouse, Lee F | | 34,005 | Win |
| D1 | 29/10/1960 | Sheffield Wednesday | 2-0 | Bolton Wanderers | | | 25,708 | Loss |
| LC2 | 26/10/1960 | Bolton Wanderers | 6-2 | Grimsby Town | Hill, Stevens D, Lofthouse 3, Keeble (og) | | 7,992 | Win |
| D1 | 22/10/1960 | Bolton Wanderers | 0-3 | Fulham | | | 19,816 | Loss |
| LC1R | 19/10/1960 | Bolton Wanderers | 5-1 | Hull City | Birch, Hill 2, McAdams 2 | | 10,781 | Win |
| D1 | 15/10/1960 | Cardiff City | 0-1 | Bolton Wanderers | Lofthouse | | 22,672 | Win |
| LC1 | 10/10/1960 | Hull City | 0-0 | Bolton Wanderers | | | 11,890 | Draw |
| D1 | 08/10/1960 | Bolton Wanderers | 0-1 | West Bromwich Albion | | | 18,672 | Loss |
| D1 | 01/10/1960 | Bolton Wanderers | 1-1 | Manchester United | McAdams | | 39,197 | Draw |
| D1 | 24/09/1960 | Blackburn Rovers | 3-1 | Bolton Wanderers | Hartle (pen) | | 29,236 | Loss |
| D1 | 17/09/1960 | Bolton Wanderers | 3-4 | Everton | McAdams, Parry R, Hill | | 30,405 | Loss |
| D1 | 14/09/1960 | Tottenham Hotspur | 3-1 | Bolton Wanderers | McAdams | | 43,559 | Loss |
| D1 | 10/09/1960 | Blackpool | 0-1 | Bolton Wanderers | Hill | | 17,166 | Win |
| D1 | 07/09/1960 | Bolton Wanderers | 1-2 | Tottenham Hotspur | McAdams | | 41,565 | Loss |
| D1 | 03/09/1960 | Bolton Wanderers | 4-1 | Chelsea | Edwards G B, Holden D, McAdams 2 | | 21,609 | Win |
| D1 | 31/08/1960 | Wolverhampton Wanderers | 3-1 | Bolton Wanderers | Banks T | | 37,313 | Loss |
| D1 | 27/08/1960 | West Ham United | 2-1 | Bolton Wanderers | Deakin P | | 24,283 | Loss |
| D1 | 24/08/1960 | Bolton Wanderers | 0-2 | Wolverhampton Wanderers | | | 20,132 | Loss |
| D1 | 20/08/1960 | Bolton Wanderers | 2-2 | Birmingham City | Birch, Parry R | | 20,543 | Draw |