| L1 | 30/04/2022 | Bolton Wanderers | 4-2 | Fleetwood Town | Dion Charles, Declan John, Dion Charles, Jan Dadi Bodvarsson | Highlights | 16,886 | Win |
| L1 | 23/04/2022 | Cheltenham Town | 1-2 | Bolton Wanderers | Keiran Sadlier, Amadou Bakayoko | Highlights | 5,228 | Win |
| L1 | 18/04/2022 | Bolton Wanderers | 3-1 | Accrington Stanley | Dapo Afolayan, Jon Dadi Bodvarsson, Jon Dadi Bodvarsson | Highlights | 19,098 | Win |
| L1 | 15/04/2022 | Doncaster Rovers | 1-2 | Bolton Wanderers | Amadou Bakayoko, Keiran Sadlier | Highlights | 8,668 | Win |
| L1 | 09/04/2022 | Bolton Wanderers | 1-1 | Sheffield Wednesday | MJ Williams | Highlights | 19,164 | Draw |
| L1 | 02/04/2022 | Wigan Athletic | 1-1 | Bolton Wanderers | Jon Dadi Bodvarsson | Highlights | 15,279 | Draw |
| L1 | 26/03/2022 | Bolton Wanderers | 1-1 | Portsmouth | Keiran Sadlier | Highlights | 13,809 | Draw |
| L1 | 19/03/2022 | Crewe Alexandra | 0-1 | Bolton Wanderers | Amadou Bakayoko | Highlights | 5,985 | Win |
| L1 | 12/03/2022 | Bolton Wanderers | 0-1 | Plymouth Argyle | | Highlights | 16,078 | Loss |
| L1 | 08/03/2022 | Bolton Wanderers | 1-1 | Morecambe | Jon Dadi Bodvarsson | Highlights | 14,559 | Draw |
| L1 | 05/03/2022 | Gillingham | 0-3 | Bolton Wanderers | Aaron Morley, Declan John, Jon Dadi Bodvarsson | Highlights | 5,109 | Win |
| L1 | 26/02/2022 | Milton Keynes Dons | 2-0 | Bolton Wanderers | | Highlights | 10,388 | Loss |
| L1 | 22/02/2022 | Bolton Wanderers | 3-1 | Lincoln City | George Johnston, Keiran Sadlier, Amadou Bakayoko | Highlights | 13,841 | Win |
| L1 | 19/02/2022 | Bolton Wanderers | 4-0 | AFC Wimbledon | Jon Dadi Bodvarsson, Oladapo Afolayan, Dion Charles, Amadou Bakayoko | Highlights | 14,537 | Win |
| L1 | 15/02/2022 | Burton Albion | 3-1 | Bolton Wanderers | Dion Charles | Highlights | 3,487 | Loss |
| L1 | 12/02/2022 | Oxford United | 2-3 | Bolton Wanderers | Declan John, Marlon Fossey, Amadou Bakayoko | Highlights | 10,027 | Win |
| L1 | 08/02/2022 | Bolton Wanderers | 2-1 | Charlton Athletic | Dion Charles, Will Aimson | Highlights | 13,523 | Win |
| L1 | 05/02/2022 | Morecambe | 1-1 | Bolton Wanderers | Amadou Bakayoko | Highlights | 5,617 | Draw |
| L1 | 01/02/2022 | Bolton Wanderers | 2-0 | Cambridge United | Amadou Bakayoko, Oladapo Afolyan | Highlights | 13,334 | Win |
| L1 | 29/01/2022 | Bolton Wanderers | 6-0 | Sunderland | Dion Charles, Dapo Afolayan, Dion Charles, Kieran Lee, Own Goal, Declain John | Highlights | 20,059 | Win |
| L1 | 22/01/2022 | Shrewsbury Town | 0-1 | Bolton Wanderers | Dion Charles | Highlights | 8,027 | Win |
| L1 | 15/01/2022 | Bolton Wanderers | 2-0 | Ipswich Town | Keiran Lee, Aladapo Afolayan | Highlights | 14,020 | Win |
| L1 | 11/01/2022 | Bolton Wanderers | 0-2 | Wycombe Wanderers | | Highlights | 12,584 | Loss |
| EFLT | 04/01/2022 | Hartlepool | 1-0 | Bolton Wanderers | | Highlights | 2,529 | Loss |
| L1 | 01/01/2022 | Rotherham United | 2-1 | Bolton Wanderers | Eoin Doyle | Highlights | 9,736 | Loss |
| L1 | 11/12/2021 | Accrington Stanley | 1-0 | Bolton Wanderers | | Highlights | 4,546 | Loss |
| L1 | 07/12/2021 | Fleetwood Town | 3-0 | Bolton Wanderers | | Highlights | 3,279 | Loss |
| L1 | 27/11/2021 | Bolton Wanderers | 2-2 | Cheltenham Town | Xavier Amaechi, Elias Kachunga | Highlights | 13,145 | Draw |
| L1 | 23/11/2021 | Bolton Wanderers | 3-0 | Doncaster Rovers | Eoin Doyle | Highlights | 12,501 | Win |
| L1 | 20/11/2021 | Wycombe Wanderers | 1-0 | Bolton Wanderers | | Highlights | 5,710 | Loss |
| FAC1R | 17/11/2021 | Stockport County | 5-3 | Bolton Wanderers | Elias Kachunga, Own Goal, Amadou Bakayoko | Highlights | 10,084 | Loss |
| L1 | 12/11/2021 | Bolton Wanderers | 2-0 | Crewe Alexandra | Josh Sheehan, Amadou Bakayoko | Highlights | 13,804 | Win |
| EFLT | 09/11/2021 | Rochdale | 0-3 | Bolton Wanderers | Oladapo Afolayan, Declan John, Eoin Doyle | Highlights | 1,116 | Win |
| FAC1 | 07/11/2021 | Bolton Wanderers | 2-2 | Stockport County | Eoin Doyle, Elias Kachunga | Highlights | 11,183 | Draw |
| L1 | 30/10/2021 | Portsmouth | 1-0 | Bolton Wanderers | | Highlights | 16,231 | Loss |
| L1 | 23/10/2021 | Bolton Wanderers | 2-2 | Gillingham | Oladapo Afolayan, Keiran Lee | Highlights | 13,807 | Draw |
| L1 | 19/10/2021 | Plymouth Argyle | 3-0 | Bolton Wanderers | | Highlights | 12,813 | Loss |
| L1 | 16/10/2021 | Bolton Wanderers | 0-4 | Wigan Athletic | | Highlights | 20,892 | Loss |
| L1 | 09/10/2021 | Sheffield Wednesday | 1-0 | Bolton Wanderers | | Highlights | 23,692 | Loss |
| EFLT | 05/10/2021 | Bolton Wanderers | 4-1 | Liverpool U21 | Nathan Delfouneso, Amadou Bakayoko, Own Goal, Amadou Bakayoko, | Highlights | 2,299 | Win |
| L1 | 02/10/2021 | Bolton Wanderers | 2-1 | Shrewsbury Town | Antoni Sarcevic, Oladapo Afolayan | Highlights | 14,124 | Win |
| L1 | 28/09/2021 | Charlton Athletic | 1-4 | Bolton Wanderers | Oladapo Afolayan, Kieran Lee, Kieran Lee, Antoni Sarcevic | Highlights | 12,707 | Win |
| L1 | 25/09/2021 | Sunderland | 1-0 | Bolton Wanderers | | Highlights | 32,368 | Loss |
| L1 | 18/09/2021 | Bolton Wanderers | 0-2 | Rotherham United | | Highlights | 20,877 | Loss |
| L1 | 11/09/2021 | Ipswich Town | 2-5 | Bolton Wanderers | Dapo Afolyan, Eoin Doyle, Dapo Afolayan, Josh Sheehan, George Johnstone | Highlights | 19,267 | Win |
| L1 | 04/09/2021 | Bolton Wanderers | 0-0 | Burton Albion | | Highlights | 13,305 | Draw |
| EFLT | 31/08/2021 | Bolton Wanderers | 3-2 | Port Vale | Eoin Doyle, Nathan Delfouneso, Oladapo Afolayan | Highlights | 2,926 | Win |
| L1 | 28/08/2021 | Cambridge United | 1-0 | Bolton Wanderers | | Highlights | 6,124 | Loss |
| LC2 | 24/08/2021 | Wigan Athletic | 0-0 | Bolton Wanderers | | Highlights | 11,660 | Draw |
| L1 | 21/08/2021 | Bolton Wanderers | 2-1 | Oxford United | Oladapo Afolayan, Eoin Doyle | Highlights | 15,073 | Win |
| L1 | 17/08/2021 | Lincoln City | 0-1 | Bolton Wanderers | Antoni Sarcevic | Highlights | 9,130 | Win |
| L1 | 14/08/2021 | AFC Wimbledon | 3-3 | Bolton Wanderers | Eoin Doyle, Josh Sheehan, Oladapo Afolayan | Highlights | Unknown | Draw |
| LC1 | 10/08/2021 | Bolton Wanderers | 0-0 | Barnsley | | Highlights | 7,147 | Draw |
| L1 | 07/08/2021 | Bolton Wanderers | 3-3 | Milton Keynes Dons | Josh Sheehan, Amadou Bakayoko, Alex Baptiste | Highlights | 16,087 | Draw |