| PL | 07/05/2006 | Bolton Wanderers | 1-0 | Birmingham City | Vaz Te | | 26,275 | Win |
| PL | 03/05/2006 | Bolton Wanderers | 1-1 | Middlesbrough | Vaz Te | | 22,733 | Draw |
| PL | 30/04/2006 | Tottenham Hotspur | 1-0 | Bolton Wanderers | | | 36,179 | Loss |
| PL | 22/04/2006 | Bolton Wanderers | 4-1 | Charlton Athletic | Vaz Te, Davies K (2), Borgetti | | 24,713 | Win |
| PL | 17/04/2006 | West Bromwich Albion | 0-0 | Bolton Wanderers | | | 23,181 | Draw |
| PL | 15/04/2006 | Bolton Wanderers | 0-2 | Chelsea | | | 27,266 | Loss |
| PL | 09/04/2006 | Liverpool | 1-0 | Bolton Wanderers | | | 44,194 | Loss |
| PL | 04/04/2006 | Birmingham City | 1-0 | Bolton Wanderers | | | 26,493 | Loss |
| PL | 01/04/2006 | Bolton Wanderers | 1-2 | Manchester United | Davies K | | 27,718 | Loss |
| PL | 26/03/2006 | Middlesbrough | 4-3 | Bolton Wanderers | Stelios Giannakopoulos, Jay Jay Okocha, Radhi Jaidi | Highlights | 25,971 | Loss |
| PL | 18/03/2006 | Bolton Wanderers | 2-0 | Sunderland | Davies, Nolan | | 23,568 | Win |
| FAC5R | 15/03/2006 | West Ham United | 2-1 | Bolton Wanderers | Davies (aet) | | 24,685 | Loss |
| PL | 11/03/2006 | Bolton Wanderers | 4-1 | West Ham United | Giannakopoulos 2, Speed, Pedersen | | 24,461 | Win |
| PL | 04/03/2006 | Newcastle United | 3-1 | Bolton Wanderers | Davies K | | 52,012 | Loss |
| PL | 26/02/2006 | Bolton Wanderers | 2-1 | Fulham | Helguson (og), Nolan | | 23,104 | Win |
| UC3L2 | 23/02/2006 | Olympique Marseille | 2-1 | Bolton Wanderers | Giannakopoulos | | 38,351 | Loss |
| FAC5 | 18/02/2006 | Bolton Wanderers | 0-0 | West Ham United | | | 17,120 | Draw |
| UC3L1 | 15/02/2006 | Bolton Wanderers | 0-0 | Olympique Marseille | | | 19,288 | Draw |
| PL | 11/02/2006 | Arsenal | 1-1 | Bolton Wanderers | Kevin Nolan | Highlights | 38,193 | Draw |
| PL | 04/02/2006 | Bolton Wanderers | 1-1 | Wigan Athletic | Giannakopoulos | | 25,854 | Draw |
| PL | 01/02/2006 | Portsmouth | 1-1 | Bolton Wanderers | Fadiga | | 19,128 | Draw |
| FAC4 | 28/01/2006 | Bolton Wanderers | 1-0 | Arsenal | Giannakopoulos | | 13,326 | Win |
| PL | 21/01/2006 | Bolton Wanderers | 2-0 | Manchester City | Borgetti, Nolan | | 26,466 | Win |
| PL | 14/01/2006 | Blackburn Rovers | 0-0 | Bolton Wanderers | | | 18,180 | Draw |
| FAC3 | 07/01/2006 | Watford | 0-3 | Bolton Wanderers | Borgetti, Giannakopoulos, Vaz Te | | 13,239 | Win |
| PL | 02/01/2006 | Bolton Wanderers | 2-2 | Liverpool | Jaidi, Diouf | | 27,604 | Draw |
| PL | 31/12/2005 | Manchester United | 4-1 | Bolton Wanderers | Speed | | 67,858 | Loss |
| PL | 26/12/2005 | Sunderland | 0-0 | Bolton Wanderers | | | 32,232 | Draw |
| LCQF | 20/12/2005 | Wigan Athletic | 2-0 | Bolton Wanderers | | | 13,401 | Loss |
| PL | 17/12/2005 | Everton | 0-4 | Bolton Wanderers | Davies, Giannakopoulos 2, Speed (pen) | | 34,500 | Win |
| UCG | 14/12/2005 | Bolton Wanderers | 1-1 | Sevilla | N'Gotty | | 15,623 | Draw |
| PL | 10/12/2005 | Bolton Wanderers | 1-1 | Aston Villa | El Hadji Diouf | Highlights | 23,646 | Draw |
| PL | 03/12/2005 | Bolton Wanderers | 2-0 | Arsenal | Faye, Giannakopoulos | | 26,792 | Win |
| LC4 | 30/11/2005 | Bolton Wanderers | 2-1 | Leicester City | Borgetti, Vaz Te (aet) | | 13,067 | Win |
| PL | 27/11/2005 | Fulham | 2-1 | Bolton Wanderers | Legwinski (og) | | 19,768 | Loss |
| UCG | 24/11/2005 | Vitoria Guimaraes | 1-1 | Bolton Wanderers | Vaz Te | Highlights | 20,000 | Draw |
| PL | 07/11/2005 | Bolton Wanderers | 1-0 | Tottenham Hotspur | Nolan | | 26,634 | Win |
| UCG | 03/11/2005 | Bolton Wanderers | 1-0 | Zenit St Petersburg | Nolan | Highlights | 15,905 | Win |
| PL | 29/10/2005 | Charlton Athletic | 0-1 | Bolton Wanderers | Nolan | | 26,175 | Win |
| LC3 | 26/10/2005 | Bolton Wanderers | 1-0 | West Ham United | Borgetti | | 10,927 | Win |
| PL | 23/10/2005 | Bolton Wanderers | 2-0 | West Bromwich Albion | Nakata, Nolan | | 24,151 | Win |
| UCG | 20/10/2005 | Besiktas | 1-1 | Bolton Wanderers | Borgetti | Highlights | 17,027 | Draw |
| PL | 15/10/2005 | Chelsea | 5-1 | Bolton Wanderers | Giannakopoulos | | 41,755 | Loss |
| PL | 02/10/2005 | Wigan Athletic | 2-1 | Bolton Wanderers | Jaidi | | 20,553 | Loss |
| UC1L2 | 29/09/2005 | Lokomotiv Plovdiv | 1-2 | Bolton Wanderers | Tunchev (og), Nolan | | 14,000 | Win |
| PL | 24/09/2005 | Bolton Wanderers | 1-0 | Portsmouth | Nolan | | 23,134 | Win |
| PL | 18/09/2005 | Manchester City | 0-1 | Bolton Wanderers | Gary Speed (pen) | Highlights | 43,137 | Win |
| UC1L1 | 15/09/2005 | Bolton Wanderers | 2-1 | Lokomotiv Plovdiv | Diouf, Borgetti | Highlights | 19,723 | Win |
| PL | 11/09/2005 | Bolton Wanderers | 0-0 | Blackburn Rovers | | | 24,405 | Draw |
| PL | 27/08/2005 | West Ham United | 1-2 | Bolton Wanderers | Nolan, Campo | | 31,629 | Win |
| PL | 24/08/2005 | Bolton Wanderers | 2-0 | Newcastle United | Diouf, Giannakopoulos | | 25,904 | Win |
| PL | 21/08/2005 | Bolton Wanderers | 0-1 | Everton | | | 25,608 | Loss |
| PL | 13/08/2005 | Aston Villa | 2-2 | Bolton Wanderers | Davies, Campo | | 33,263 | Draw |